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KMID : 1138520100130020051
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Journal of Pharmacopuncture
2010 Volume.13 No. 2 p.51 ~ p.65
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Anti-inflammatory Effect of Benincasae Semen Herbal-acupuncture at KI10 on nephritis in rats
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Lee Jeong-Hwan
Kim Jung-Ho
Kim Young-Il
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Abstract
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Objective : This study aimed to evaluate the effects of Benincasae Semen Herbal-acupuncture (BS-HA) at KI10 (Umgok) on nephritis induced by LPS in rat.
Methods : Rats with nephritis induced by LPS, were treated with Benincasae Semen Herbal-acupuncture(BS-HA) injection at KI10. Two control groups, N.P. group and saline group, were treated with 26 gauge needle at KI10, 3 times a week. In Saline group normal saline was injected at KI10. To evaluate the effects of Benincasae. Semen Herbal-acupuncture at KI10 on nephritis in rats, WBC, Neutrophils in blood, BUN, Creatinine TNF-, CINC-1 in serum, urinal volume and creatinine and Total protein in urine, reanl TNF-, renal MPO were measured and reanl tissue was also analyzed.
Results: BS-HA injected at KI10 significantly inhibited WBC and neutrophil in blood. creatinine in serum, and MPO in kidney of LPS-stimulated rats. BS-HA injected at KI10 reduced concentration of neutrophil in renal tissue of LPS-stimulated rats.
Conclusion : BS-HA at KI10 has a therapeutic effect for nephritis in LPS-stimulated rat There fore, it is suggested that BS-HA at KI10 may be an useful therapeutics in clinical field after further researches.
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KEYWORD
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Nephritis, Herbal-acupuncture, KI10, Benincasae Semen, LPS
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